Home to Genentech, with plenty of northern county hotels and inns, South San Francisco is nicknamed the ‚ÄúBirthplace of Biotechnology‚Äù. The city occupies the basin and portions of the sides of a broad valley formed by the San Bruno Mountains on the north and the Coast Range on the west. Most of the valley faces adjacent San Francisco Bay, affording sweeping vistas from higher levels and a definite sense of identification with the Bay. South San Francisco has mild winters and dry, cool summers. The hills to the west shield the city from much of the fog that prevails in neighboring areas. Oyster Point Marina and a Bay front trail are here, as well.