South San Francisco

Home to Genentech, with plenty of northern county hotels and inns, South San Francisco is nicknamed the “Birthplace of Biotechnology”. The city occupies the basin and portions of the sides of a broad valley formed by the San Bruno Mountains on the north and the Coast Range on the west. Most of the valley faces adjacent San Francisco Bay, affording sweeping vistas from higher levels and a definite sense of identification with the Bay. South San Francisco has mild winters and dry, cool summers. The hills to the west shield the city from much of the fog that prevails in neighboring areas. Oyster Point Marina and a Bay front trail are here, as well.

South San Francisco

STAY. MEET. EAT. and PLAY. with us!

We’ve added a handy tool to help our visitors map out their stay with us. Learn about all the things to see and do in San Mateo County/Silicon Valley.



#playbythebay Photo Contest

Date: Friday, April 28, 2017
Time: 12:00am
Find out more



Start planning your trip. Order your free visitor guide and begin recieving our newsletters today!